Dora Brites Selected Research

Bilirubin

1/2016	Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia.
2/2015	Bilirubin-induced neural impairment: a special focus on myelination, age-related windows of susceptibility and associated co-morbidities.
1/2015	Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study.
11/2014	Blood-brain barrier and bilirubin: clinical aspects and experimental data.
7/2014	Cross-talk between neurons and astrocytes in response to bilirubin: adverse secondary impacts.
2/2014	Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors.
12/2013	New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters.
4/2013	Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination.
12/2012	ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin.
5/2012	Cerebellar axon/myelin loss, angiogenic sprouting, and neuronal increase of vascular endothelial growth factor in a preterm infant with kernicterus.

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Dora Brites Research Topics

Disease

18	Inflammation (Inflammations) 01/2022 - 07/2006
14	Brain Diseases (Brain Disorder) 01/2022 - 08/2004
12	Kernicterus 01/2016 - 01/2002
8	Hyperbilirubinemia 02/2015 - 11/2004
7	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 07/2002
7	Necrosis 11/2016 - 04/2002
4	Neuroinflammatory Diseases 01/2022 - 01/2015
4	Gliosis 01/2020 - 02/2014
4	Sepsis (Septicemia) 02/2015 - 08/2004
4	Neonatal Hyperbilirubinemia 01/2015 - 12/2006
3	Multiple Sclerosis 01/2022 - 01/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 11/2016
3	Neurologic Manifestations (Neurological Manifestations) 01/2016 - 01/2010
3	Hypoxia (Hypoxemia) 02/2015 - 05/2007
3	Jaundice (Icterus) 01/2015 - 05/2011
3	Neonatal Jaundice 11/2014 - 12/2006
3	Acidosis 12/2013 - 05/2003
2	Demyelinating Diseases (Demyelinating Disease) 01/2020 - 01/2016
2	Glioma (Gliomas) 06/2019 - 01/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 03/2019 - 12/2012
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019 - 01/2015
2	Wounds and Injuries (Trauma) 05/2015 - 12/2012
2	Ischemia 04/2015 - 05/2007
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022
1	Body Weight (Weight, Body) 04/2021
1	Neoplasms (Cancer) 01/2020
1	Glioblastoma (Glioblastoma Multiforme) 06/2019
1	Cognitive Dysfunction 01/2017
1	Amyloid Plaque 01/2017
1	Frailty 12/2016
1	Edema (Dropsy) 10/2016
1	Experimental Arthritis 10/2016
1	Disease Progression 06/2016
1	Multiple Organ Failure (MODS) 02/2015
1	Acute Lung Injury 02/2015
1	Burns 02/2015
1	Mental Disorders (Mental Disorder) 01/2015
1	Parkinson Disease (Parkinson's Disease) 01/2015
1	Atrophy 07/2014
1	Seizures (Absence Seizure) 12/2013

Drug/Important Bio-Agent (IBA)

30	BilirubinIBA 01/2016 - 01/2002
9	CytokinesIBA 01/2020 - 08/2004
7	MicroRNAs (MicroRNA)IBA 01/2022 - 01/2015
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2002
5	Biomarkers (Surrogate Marker)IBA 12/2018 - 01/2012
4	Bile Acids and Salts (Bile Acids)IBA 01/2015 - 01/2002
4	Glutamic Acid (Glutamate)FDA Link 06/2012 - 04/2002
3	Pharmaceutical PreparationsIBA 01/2022 - 01/2015
3	InflammasomesIBA 05/2018 - 01/2016
3	NF-kappa B (NF-kB)IBA 02/2018 - 03/2006
3	glycoursodeoxycholic acidIBA 07/2014 - 09/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2007 - 03/2006
2	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2020 - 01/2016
2	Valproic Acid (Depakote)FDA LinkGeneric 06/2019 - 01/2017
2	Temozolomide (Temodar)FDA LinkGeneric 06/2019 - 01/2017
2	PolyphenolsIBA 02/2019 - 11/2016
2	LipopolysaccharidesIBA 01/2017 - 04/2015
2	CarrageenanIBA 10/2016 - 05/2015
2	AlbuminsIBA 12/2013 - 12/2006
2	Glucose (Dextrose)FDA LinkGeneric 12/2012 - 05/2007
2	Human Serum Albumin FDA LinkGeneric 01/2012 - 05/2011
2	Interleukin-6 (Interleukin 6)IBA 12/2010 - 02/2007
2	InterleukinsIBA 12/2010 - 09/2007
1	Pentamidine (NebuPent)FDA LinkGeneric 01/2022
1	Anti-Anxiety Agents (Anxiolytics)IBA 04/2021
1	FPS-ZM1IBA 01/2020
1	Receptor for Advanced Glycation End ProductsIBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 06/2019
1	SynaptophysinIBA 03/2019
1	Superoxide Dismutase-1IBA 01/2019
1	Amyloid (Amyloid Fibrils)IBA 01/2017
1	HMGB1 Protein (HMG1)IBA 01/2017
1	divinyl sulfoneIBA 01/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Histone Deacetylase InhibitorsIBA 01/2017
1	QuercetinIBA 11/2016
1	blueberry extractIBA 10/2016
1	Rosmarinic AcidIBA 05/2015
1	Dihydrotachysterol (AT 10)IBA 05/2015
1	Glycogen Synthase (Synthase I)IBA 04/2015
1	4- benzyl- 2- methyl- 1,2,4- thiadiazolidine- 3,5- dioneIBA 04/2015
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 04/2015
1	Insulin (Novolin)FDA Link 04/2015
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 04/2015
1	Alanine Transaminase (SGPT)IBA 04/2015
1	Erythropoietin FDA Link 02/2015
1	AntioxidantsIBA 01/2015
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 02/2014
1	Inositol (Myoinositol)IBA 12/2012
1	JNK Mitogen-Activated Protein KinasesIBA 12/2012
1	Caspase 2IBA 12/2012
1	EnzymesIBA 12/2012
1	Endoplasmic Reticulum Chaperone BiPIBA 12/2012
1	CalpainIBA 12/2012
1	Periodic AcidIBA 05/2012
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2012
1	Luxol Fast Blue MBS (Luxol fast blue)IBA 05/2012
1	CateninsIBA 01/2012

Therapy/Procedure

8	Therapeutics 01/2022 - 06/2012
1	Drug Therapy (Chemotherapy) 06/2019